Fibroblast growth factor 23 and Klotho contribute to airway inflammation
نویسندگان
چکیده
منابع مشابه
Fibroblast growth factor 23/klotho axis in chronic kidney disease.
Fibroblast growth factor-23 (FGF23) is a bone-derived hormone that regulates phosphate and 1,25-hydroxyvitamin D [1,25(OH)2D] metabolism. FGF23 binds to FGF receptor 1 with its coreceptor Klotho and maintains serum phosphate levels within the normal range by increasing renal phosphate excretion. In addition, FGF23 reduces the synthesis and accelerates the degradation of 1,25(OH)2D to reduce int...
متن کاملSoluble alpha klotho and its relation to kidney function and fibroblast growth factor-23
Alexandra Scholze, Ying Liu, Lise Pedersen, Shengqiang Xia, Heinz J. Roth, Berthold Hocher, Lars Melholt Rasmussen, and Martin Tepel Clinical Research Unit, Department of Nephrology, Odense University Hospital, Odense, Denmark; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, Cardiovascular and Renal Research, University of Southe...
متن کاملFibroblast growth factor 23 and Inflammation in CKD.
BACKGROUND AND OBJECTIVES Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with adverse clinical outcomes. This study tested the hypothesis that FGF23 is independently associated with inflammation in CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS The association between levels of FGF23 and the inflammatory markers ...
متن کاملPathophysiological implications of fibroblast growth factor-23 and Klotho and their potential role as clinical biomarkers.
BACKGROUND Fibroblast growth factor-23 (FGF-23) and Klotho constitute the main regulatory system of phosphorus homeostasis. Beyond this physiological role, there is growing evidence suggesting that this system has relevant pathophysiological implications in different clinical processes. CONTENT In this review we discuss the pathophysiological implications of the FGF-23/Klotho system and the p...
متن کاملFibroblast growth factor 23 and soluble klotho in children with chronic kidney disease.
BACKGROUND Fibroblast growth factor 23 (FGF23), a bone-derived phosphaturic hormone, is elevated in chronic kidney disease (CKD). There are scarce data on the levels of its essential co-receptor klotho, and longitudinal changes in FGF23 levels are also unknown. METHODS We examined FGF23 and soluble klotho (s-klotho) levels over 1 year in 154 children with CKD Stages 1-5 (CKD1-5), were on dial...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2018
ISSN: 0903-1936,1399-3003
DOI: 10.1183/13993003.00236-2018